The Journal of allergy and clinical immunology
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J. Allergy Clin. Immunol. · Jun 2006
Review Case ReportsSuccessful treatment of cold-induced urticaria/anaphylaxis with anti-IgE.
A case of a girl who presented at age 12 years with idiopathic cold urticaria is described. Her reactions to the cold became progressively more severe over a period of approximately 2 years, despite therapy with H1 antagonists and a type 1 receptor for cysteinyl leukotrienes receptor antagonist. ⋯ A trial of anti-IgE resulted in complete resolution of her urticaria and its associated manifestations. These findings should prompt a reexamination of the potential pathogenetic role played by IgE and its high-affinity receptor on mast cells in idiopathic cold urticaria.
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J. Allergy Clin. Immunol. · Jun 2006
Randomized Controlled TrialBronchodilator responses in Chinese children from asthma index families and the general population.
Although airway hyperresponsiveness to bronchoconstrictors has been extensively investigated, epidemiologic studies on airway hyperresponsiveness to bronchodilators are limited. ⋯ Because BDR can be affected by multiple factors, interpretation of clinical or research findings on BDR needs to take these factors into consideration.
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J. Allergy Clin. Immunol. · Jun 2006
Cytokine production by bronchoalveolar lavage T lymphocytes in chronic obstructive pulmonary disease.
T lymphocytes (predominantly CD8+ cells) have previously been implicated in the pathogenesis of chronic obstructive pulmonary disease (COPD). ⋯ These cells might be a source of TH2 cytokines, which might, at least in part, explain the lung eosinophilia associated with COPD exacerbations.
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J. Allergy Clin. Immunol. · Jun 2006
Spatial clustering of the IgE epitopes on the major timothy grass pollen allergen Phl p 1: importance for allergenic activity.
The major timothy grass pollen allergen Phl p 1 is one of the most potent and frequently recognized environmental allergens. ⋯ Geographic distribution of IgE epitopes on an allergen might influence its allergenic activity and hence explain discrepancies between diagnostic test results based on IgE serology and provocation testing. It might also form a basis for the development of low allergenic vaccines.
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Approximately 40% of patients with chronic idiopathic urticaria have antibodies to the alpha subunit of the high-affinity IgE receptor. CD203c is a basophil activation marker known to be upregulated by cross-linking of the FcepsilonRIalpha receptor and may serve as a useful marker to identify these patients. ⋯ This article describes an activation marker on basophils whose expression is increased by sera from patients with chronic idiopathic urticaria.