The Journal of allergy and clinical immunology
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J. Allergy Clin. Immunol. · Jun 2006
Spatial clustering of the IgE epitopes on the major timothy grass pollen allergen Phl p 1: importance for allergenic activity.
The major timothy grass pollen allergen Phl p 1 is one of the most potent and frequently recognized environmental allergens. ⋯ Geographic distribution of IgE epitopes on an allergen might influence its allergenic activity and hence explain discrepancies between diagnostic test results based on IgE serology and provocation testing. It might also form a basis for the development of low allergenic vaccines.