The Journal of allergy and clinical immunology
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J. Allergy Clin. Immunol. · Sep 2006
Prenatal initiation of endotoxin airway exposure prevents subsequent allergen-induced sensitization and airway inflammation in mice.
New preventive strategies against the development of allergic diseases focus on potentially immunomodulatory components, such as bacterial LPSs. Optimal time frames for initiating immunomodulation to receive a sufficient effect against allergen sensitization are still unclear. ⋯ Immunomodulation with bacterial compounds during gestation time might be an effective mode for first-step primary prevention against allergic diseases.