The Journal of allergy and clinical immunology
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J. Allergy Clin. Immunol. · Oct 2009
Randomized Controlled Trial Multicenter StudyEfficacy of human C1 esterase inhibitor concentrate compared with placebo in acute hereditary angioedema attacks.
Hereditary angioedema caused by C1 esterase inhibitor deficiency is a rare disorder. ⋯ C1 esterase inhibitor concentrate given intravenously at a dose of 20 U/kg is an effective and safe treatment for acute abdominal and facial attacks in patients with hereditary angioedema, with a rapid onset of relief.
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J. Allergy Clin. Immunol. · Oct 2009
Randomized Controlled TrialExhaled nitric oxide levels in asthma: Personal best versus reference values.
Factors affecting the fraction of nitric oxide in exhaled air (FE(NO)) are multiple. Interpreting values when assessing airways disease may be problematic. Clinically optimum levels have not been defined. ⋯ Optimum FE(NO) levels are best established by using oral rather than inhaled steroid treatment, and these approximate to predicted values from the reference equation by Olin et al. However, at optimized doses of inhaled corticosteroid, although FE(NO) levels were higher than predicted, asthma was well controlled. Targeting FE(NO) on reference values is not justified.