The Journal of allergy and clinical immunology
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J. Allergy Clin. Immunol. · Aug 2009
Exploring the repertoire of IgE-binding self-antigens associated with atopic eczema.
Atopic eczema (AE) is the most common chronic inflammatory skin disease. Recent data demonstrate the presence of autoreactive serum IgE antibodies correlating with the severity of the disease. ⋯ These data demonstrate a broad spectrum of at least 140 IgE-binding self-antigens associated with AE. By binding IgE antibodies or activating specific T cells, they might promote, perpetuate, or both existing skin inflammation.
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J. Allergy Clin. Immunol. · Aug 2009
Multicenter StudyPhenotype of atopic dermatitis subjects with a history of eczema herpeticum.
A subset of subjects with atopic dermatitis (AD) are susceptible to serious infections with herpes simplex virus, called eczema herpeticum, or vaccina virus, called eczema vaccinatum. ⋯ Subjects with AD in whom eczema herpeticum develops have more severe T(H)2-polarized disease with greater allergen sensitization and more commonly have a history of food allergy, asthma, or both. They are also much more likely to experience cutaneous infections with S. aureus or molluscum contagiosum.
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J. Allergy Clin. Immunol. · Aug 2009
Comparative StudyPrevalence of obstructive sleep apnea-hypopnea in severe versus moderate asthma.
Previous studies have suggested a link between obstructive sleep apnea and poor asthma control, which may be mediated through airway inflammation, obesity, and other mechanisms. ⋯ Obstructive sleep apnea-hypopnea was significantly more prevalent among patients with severe compared with moderate asthma, and more prevalent for both asthma groups than controls without asthma. These observations suggest potential pathophysiologic interactions between obstructive sleep apnea-hypopnea and asthma severity and control.
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J. Allergy Clin. Immunol. · Aug 2009
Randomized Controlled TrialAsthma morbidity among inner-city adolescents receiving guidelines-based therapy: role of predictors in the setting of high adherence.
With the expanding effort to provide guidelines-based therapy to adolescents with asthma, attention must be directed to evaluating which factors predict future asthma control when guidelines-based management is applied. ⋯ Our findings demonstrate that the usual predictors of future disease activity have little predictive power when applied to a highly adherent population with persistent asthma that is receiving guidelines-based care. Thus, new predictors need to be identified that will be able to measure the continued fluctuation of disease that persists in highly adherent, well-treated populations such as the one studied.