The Journal of allergy and clinical immunology
-
J. Allergy Clin. Immunol. · Aug 2010
Multicenter Study Comparative Study Clinical TrialThe effect of respiratory syncytial virus on subsequent recurrent wheezing in atopic and nonatopic children.
Although respiratory syncytial virus (RSV) lower respiratory tract infections (LRTIs) in early life are followed by later airway hyperreactivity, it is unclear whether there is a causal relationship between this and an atopic diathesis. ⋯ Respiratory syncytial virus prophylaxis in nonatopic children decreases by 80% the relative risk of recurrent wheezing but does not have any effect in infants with an atopic family history. This suggests that RSV predisposes to recurrent wheezing in an atopy-independent mechanism.
-
J. Allergy Clin. Immunol. · Aug 2010
Expression of IL-4 receptor alpha on smooth muscle cells is not necessary for development of experimental allergic asthma.
Airflow in the lungs of patients with allergic asthma is impaired by excessive mucus production and airway smooth muscle contractions. Elevated levels of the cytokines IL-4 and IL-13 are associated with this pathology. In vitro studies have suggested that IL-4 receptor alpha (IL-4Ralpha) signaling on smooth muscle cells is critical for airway inflammation and airway hyperresponsiveness. ⋯ The impairment of IL-4Ralpha on smooth muscle cells had no effect on major etiologic markers of allergic asthma. These findings suggest that IL-4Ralpha responsiveness in airway smooth muscle cells during the early phase of allergic asthma is not, as suggested, necessary for the outcome of the disease.
-
J. Allergy Clin. Immunol. · Aug 2010
Letter Randomized Controlled Trial Multicenter StudyRisk of cataracts in the Childhood Asthma Management Program Cohort.