The Journal of allergy and clinical immunology
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J. Allergy Clin. Immunol. · Oct 2012
Corticosteroid insensitivity of chemokine expression in airway smooth muscle of patients with severe asthma.
Patients with severe asthma are less responsive to the beneficial effects of corticosteroid therapy. ⋯ ASMCs of patients with severe asthma are corticosteroid insensitive; this might be secondary to heightened p38 mitogen-activated protein kinase levels.