The Journal of allergy and clinical immunology
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J. Allergy Clin. Immunol. · Jul 2012
Case-control admixture mapping in Latino populations enriches for known asthma-associated genes.
Polymorphisms in more than 100 genes have been associated with asthma susceptibility, yet much of the heritability remains to be explained. Asthma disproportionately affects different racial and ethnic groups in the United States, suggesting that admixture mapping is a useful strategy to identify novel asthma-associated loci. ⋯ Case-control admixture mapping is a promising strategy for identifying novel asthma-associated loci in Latino populations and implicates genetic variation at 6q15 and 8q12 regions with asthma susceptibility. This approach might be useful for identifying regions that contribute to both shared and population-specific differences in asthma susceptibility.
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J. Allergy Clin. Immunol. · Jul 2012
Ventilation heterogeneity predicts asthma control in adults following inhaled corticosteroid dose titration.
Asthma guidelines recommend inhaled corticosteroid (ICS) dose titration for patients on the basis of an assessment of current asthma control. However, the physiological determinants of asthma symptom control are poorly understood and spirometry is a poor predictor of symptomatic response. ⋯ Ventilation heterogeneity predicts symptomatic responses to ICS dose titration. Worse small airways function predicts symptomatic improvement to ICS dose uptitration and loss of symptom control during downtitration.
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J. Allergy Clin. Immunol. · Jul 2012
Novel severe wheezy young children phenotypes: boys atopic multiple-trigger and girls nonatopic uncontrolled wheeze.
Recurrent wheezing during infancy is a heterogeneous disorder that has been associated with early-onset asthma. ⋯ We identified different phenotypes of recurrent wheezing in young children by using cluster analysis with usual variables. These phenotypes require confirmation in longer, follow-up studies.