The Journal of allergy and clinical immunology
-
J. Allergy Clin. Immunol. · Dec 2017
Viral reactivations and associated outcomes in the context of immune reconstitution after pediatric hematopoietic cell transplantation.
Viral reactivations (VRs) after hematopoietic cell transplantation (HCT) contribute to significant morbidity and mortality. Timely immune reconstitution (IR) is suggested to prevent VR. ⋯ These results stress the importance of timely CD4 reconstitution. Strategies to improve CD4 reconstitution can improve HCT outcomes, including survival, and reduce the need for toxic antiviral therapies.