The Journal of allergy and clinical immunology
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J. Allergy Clin. Immunol. · Mar 2017
Randomized Controlled TrialAberrant IgA responses to the gut microbiota during infancy precede asthma and allergy development.
Although a reduced gut microbiota diversity and low mucosal total IgA levels in infancy have been associated with allergy development, IgA responses to the gut microbiota have not yet been studied. ⋯ An aberrant IgA responsiveness to the gut microbiota during infancy precedes asthma and allergy development, possibly indicating an impaired mucosal barrier function in allergic children.