The Journal of allergy and clinical immunology
-
J. Allergy Clin. Immunol. · Jun 2017
The role of microRNA-155/LXR pathway in experimental and Idiopathic Pulmonary Fibrosis.
Idiopathic pulmonary fibrosis (IPF) is progressive and rapidly fatal. Improved understanding of pathogenesis is required to prosper novel therapeutics. Epigenetic changes contribute to IPF; therefore, microRNAs may reveal novel pathogenic pathways. ⋯ We describe herein a molecular pathway comprising miR-155 and its epigenetic LXRα target that when deregulated enables pathogenic pulmonary fibrosis. Manipulation of the miR-155/LXR pathway may have therapeutic potential for IPF.