The Journal of allergy and clinical immunology
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J. Allergy Clin. Immunol. · Dec 2021
A genomic approach identifies sRAGE as a putatively causal protein for asthma.
Asthma is a complex respiratory condition caused by environmental and genetic factors. Although lower concentrations of the anti-inflammatory protein sRAGE have been associated with asthma in humans and mouse models, it is uncertain whether sRAGE plays a causal role in asthma. ⋯ Through this genomic approach, we identified sRAGE as a putatively causal, biologically important, and protective protein in relation to asthma. Functional studies in cell/animal models are needed to confirm our findings.