The Journal of allergy and clinical immunology
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J. Allergy Clin. Immunol. · Jul 2011
Randomized Controlled Trial Multicenter StudyEfficacy and safety of omalizumab in patients with chronic urticaria who exhibit IgE against thyroperoxidase.
A subgroup of patients with chronic spontaneous urticaria (CU) exhibits IgE antibodies directed against autoantigens, such as thyroperoxidase (TPO). We conducted this study to investigate whether such patients with CU with IgE against TPO benefit from treatment with omalizumab, a humanized anti-IgE mAb licensed for the treatment of severe persistent allergic (IgE-mediated) asthma. ⋯ The results of this study indicate that omalizumab is an effective treatment option for patients with CU with IgE autoantibodies against TPO who are refractory to conventional treatment.
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J. Allergy Clin. Immunol. · Jul 2011
Increased expression of the chemokine CCL23 in eosinophilic chronic rhinosinusitis with nasal polyps.
Chronic rhinosinusitis (CRS) is a heterogeneous chronic disease characterized by local inflammation of the sinonasal tissues. The pathogenesis of CRS remains controversial, but it has been associated with the accumulation of various immune and inflammatory cells in sinus tissue. ⋯ Overproduction of CCL23 in NPs might contribute to the pathogenesis of eosinophilic CRSwNP through the recruitment of CCR1(+) inflammatory cells, including monocytes and macrophages, and the amplification of local inflammation.
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J. Allergy Clin. Immunol. · Jul 2011
Cosmopolitan and ethnic-specific replication of genetic risk factors for asthma in 2 Latino populations.
Although Mexicans and Puerto Ricans are jointly classified as "Hispanic/Latino," there are significant differences in asthma prevalence, severity, and mortality between the 2 groups. We sought to examine the possibility that population-specific genetic risks contribute to this disparity. ⋯ Our results show that only a minority of genetic association studies replicate in our population of Mexican and Puerto Rican asthmatic subjects. Among SNPs that were successfully replicated, most showed no significant heterogeneity across populations. However, we identified several population-specific genetic associations.
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J. Allergy Clin. Immunol. · Jul 2011
Reduced breath condensate pH in asymptomatic children with prior wheezing as a risk factor for asthma.
Early noninvasive detection of increased risk of asthma with exhaled breath condensate (EBC) pH measurement has not been applied to preschool children. ⋯ A reduced deaerated EBC pH value might help identify young asymptomatic children at high risk of asthma.
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J. Allergy Clin. Immunol. · Jun 2011
Multicenter Study Comparative StudyObesity and asthma: an association modified by age of asthma onset.
Studies of asthma phenotypes have identified obesity as a component of a group characterized by a high proportion of subjects with adult-onset asthma. However, whether age of asthma onset modifies the association between obesity and asthma is unknown. ⋯ Asthmatic subjects are differentially affected by obesity based on whether they had asthma early (<12 years of age) or later in life. These results highlight the need to understand obesity as a comorbidity that affects specific clinical phenotypes and not all asthma subjects alike.