Anesthesiology
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Comparative Study
Assessment of postischemic neurogenesis in rats with cerebral ischemia and propofol anesthesia.
Postischemic endogenous neurogenesis can be dose-dependently modulated by volatile anesthetics. The intravenous anesthetic propofol is used during operations with a risk of cerebral ischemia, such as neurosurgery, cardiac surgery, and vascular surgery. The effects of propofol on neurogenesis are unknown and, therefore, the object of this study. ⋯ Independent effects of propofol are difficult to ascertain. Peri-ischemic propofol administration may exert secondary effects on neurogenesis by modulating the severity of histopathologic injury and thereby regenerative capacity of the hippocampus.
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Editorial Comment
Goal-directed perioperative fluid management: why, when, and how?