Clinica chimica acta; international journal of clinical chemistry
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Comparative Study
Comparison of novel pro-BNP(1-108) and standard BNP assays in heart failure patients.
Heart failure (HF) progression and outcomes reflect activation of multiple neurohormonal systems. Which biomarkers reflecting these systems contribute incremental information remains unclear. The aim of this study was to determine if serial measurements of pro-BNP(1-108) separately, in combination with standard assay BNP, or with troponin T (cTnT) would enhance risk stratification in ambulatory HF patients. ⋯ Circulating levels of pro-BNP(1-108) appear to be comparable to mature BNP in ambulatory HF out-patients. Elevated levels of pro-BNP(1-108) or BNP identified by serial monitoring similarly predict events. A strategy of serial monitoring of either pro-BNP(1-108) or BNP alone or particularly in combination with cTnT can serve a valuable role in detecting higher-risk HF patients.
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Comparative Study
Prognostic value of combining high sensitive troponin T and N-terminal pro B-type natriuretic peptide in chest pain patients with no persistent ST-elevation.
The aim was to examine whether high sensitive troponin T (Hs-TnT) is better than conventional troponins to risk stratify chest pain patients, in particular when applying early serial measurements or combining with natriuretic peptides. Samples were obtained on admission and after 2 h in 231 chest pain patients who were followed for a median time of 22 months. Troponin levels were determined by Hs-TnT, conventional TnT (Roche Diagnostics) and troponin I (Beckman Coulter) assays. ⋯ In those with negative TnI, Hs-TnT identified 26 patients of whom 23% had subsequent events. After adjusting for differences in baseline characteristics, both Hs-TnT and NT-proBNP were independently associated with short-term (3 months) risk of combined endpoint and long-term risk of death or MI. By combining Hs-TnT and NT-proBNP patients could be divided into low-, intermediate- and high-risk groups.