Clinica chimica acta; international journal of clinical chemistry
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Observational Study
Increased admission serum cold-inducible RNA-binding protein concentration is associated with prognosis of severe acute pancreatitis.
Cold-inducible RNA-binding protein (CIRP) is a pro-inflammatory cytokine. This study assessed its relation to disease severity and major adverse events (namely local complications, organ failure and in-hospital mortality) of severe acute pancreatitis (SAP) and its discriminatory ability for SAP. ⋯ Increased serum CIRP concentrations clearly reflect SAP severity and prognosis and significantly distinguish SAP, substantializing CIRP as a potential SAP biomarker.