Plastic and reconstructive surgery
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Plast. Reconstr. Surg. · Aug 1980
The early enzymatic debridement and grafting of deep dermal burns to the hand.
Thirty-four hands in 24 patients with clinically diagnosed, deep second-degree burns have been treated for 24 hours, immediately after the burn with Sutilains bacterial enzymatic ointment. The ages of the patients range from 16 months to 65 years. ⋯ Ninety-one percent had full take of the grafts and were able to move their hands actively and passively through a full range of movement within 1 week after the burn. The long-term aesthetic and functional results were excellent.
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Plast. Reconstr. Surg. · Aug 1980
In vivo microcirculation of a scald burn and the progression of postburn dermal ischemia.
The homozygous hairless mouse ear provides a reproducible model for the study of the microcirculatory changes of the burn wound during and following a scald burn injury. This model has allowed us to correlate the dynamic changes of the microcirculation to progressive zones of injury, which show an approximate tenfold increase in the area of complete capillary occlusion during the first 48 hours after injury. Platelet thromboembolism appears to be the major factor causing this progression of postburn dermal ischemia. Edema (increased skin water content) was greatest in the burned ear at 6 hours after the burn (20 percent greater than control values); edema of the unburned, contralateral ear was significant at 2 hours after the burn (9 percent greater than control values).
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Plast. Reconstr. Surg. · Apr 1980
Irrigating solutions for small blood vessel surgery--a histologic comparison.
Rat femoral vessels were clamped and perfused internally in situ for 30 minutes using five different irrigating solutions (normal saline, lactated Ringer's solution, Normosol R, pH 6.2 and 7.4, and glutathione buffered Ringer's solution). After the blood flow was reestablished, the vessels were excised at 30 minutes or 48 hours after irrigation and were sectioned longitudinally for light microscopy. ⋯ None of the agents tested proved biochemically atraumatic, and none were consistently superior to lactated Ringer's solution. Endothelial hyperplasia and platelet deposition were unexpectedly frequent findings at 48 hours.