Seminars in arthritis and rheumatism
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Semin. Arthritis Rheum. · Apr 2001
The safety and efficacy of interleukin-1 receptor antagonist in the treatment of rheumatoid arthritis.
Interleukin (IL)-1 has been associated with joint inflammation and damage in rheumatoid arthritis (RA). Endogenous IL-1 receptor antagonist (IL-1Ra) may inhibit IL-1-mediated effects by binding to the IL-1 receptors. ⋯ These studies suggest an important role for IL-1ra as a novel therapeutic agent in the treatment of RA.