Seminars in arthritis and rheumatism
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Semin. Arthritis Rheum. · Dec 2016
Meta AnalysisGray matter abnormalities associated with fibromyalgia: A meta-analysis of voxel-based morphometric studies.
Studies employing voxel-based morphometry (VBM) have reported inconsistent findings on the association of gray matter (GM) abnormalities with fibromyalgia. The aim of the present study is to identify the most prominent and replicable GM areas that involved in fibromyalgia. ⋯ The current meta-analysis identified a characteristic pattern of GM alterations within the medial pain system, default mode network, and cerebro-cerebellar circuits, which further supports the concept that fibromyalgia is a symptom complex involving brain areas beyond those implicated in chronic pain.