Seminars in arthritis and rheumatism
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Semin. Arthritis Rheum. · Aug 2018
Review Meta AnalysisEvidence of reduced parasympathetic autonomic regulation in inflammatory joint disease: A meta-analyses study.
Rheumatoid arthritis (RA) and spondyloarthritis (SpA) are inflammatory joint disorders (IJD) with increased risk of cardiovascular disease (CVD). Autonomic dysfunction (AD) is a risk factor for CVD, and parasympathetic AD is linked to key features of IJD such as inflammation, physical inactivity and pain. Heart-rate variability (HRV) is a marker of cardiac AD. The study objective was to compare parasympathetic cardiac AD, measured by HRV, between patients with IJD and healthy controls, using meta-analysis methodology, and to examine the impact of inflammation, physical inactivity and pain on HRV in IJD. ⋯ Patients with IJD have cardiac parasympathetic AD which is related to inflammation.