Neuropsychologia
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Comparative Study
Impaired recognition of negative facial emotions in patients with frontotemporal dementia.
Patients with behavioral variant of frontotemporal dementia (FTD) have difficulties recognizing facial emotions, a deficit that may contribute to their impaired social skills. In three experiments, we investigated the FTD deficit in recognition of facial emotions, by comparing six patients with impaired social conduct, nine Alzheimer's patients, and 10 age-matched healthy adults. Experiment 1 revealed that FTD patients were impaired in the recognition of negative facial emotions. ⋯ Experiment 3 was a control study in which participants had to discriminate whether two faces were of the same sex. In this non-emotional processing task, both patient groups performed worse than normal participants, but FTD patients performed as well as Alzheimer's patients. We conclude that FTD patients are impaired in the recognition of negative facial emotions.
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Since Salk [Salk, L. (1960). The effects of the normal heartbeat sound on the behavior of the new-born infant: implications for mental health. World Mental Health 12, 168-175] reported a left-side preference for cradling an infant, several studies have attempted to elucidate the origin of this bias. ⋯ The most significant finding concerns the links between the preferred visual field and the preferred holding side. This effect was observed in the sample of women, in right-handers, and in the sub-group of participants with care-giving skills. These findings suggest a leading role for the right hemisphere for side of holding.
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Many lesion experiments have provided evidence that the hippocampus plays a time-limited role in memory, consistent with the operation of a systems-level memory consolidation process during which lasting neocortical memory traces become established [see Squire, L. R., Clark, R. E., & Knowlton, B. ⋯ Partially lesioned rats could be reminded of a recently learned platform location, but no recovery of remote memory was observed. These results offer no support for hippocampus-dependent consolidation of allocentric spatial information, and suggest that the hippocampus can play a long-lasting role in spatial memory. The nature of this role--in the storage, retrieval, or expression of memory--is discussed.
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Clinical Trial Controlled Clinical Trial
Event-related potentials for response inhibition in Parkinson's disease.
This study investigated inhibitory function in patients with Parkinson's disease (PD) by recording event-related brain potentials (ERPs) during a Go/NoGo task. Fourteen healthy volunteers and 13 patients with PD without dementia performed a cued continuous performance test that included Go and NoGo trials. The peak latency, amplitude, and topographic distributions of the ERPs to Go and NoGo stimuli were analyzed. ⋯ The NoGo-P3 amplitude was significantly correlated with the WCST and VFT scores, as well as with the number of commission errors. There were no significant correlations between the cognitive function tests and either the Go-P3 or NoGo-N2 measures. The behavioral and ERP data suggest that there is selective impairment of inhibitory function in PD and that this deficit may be related to impaired inhibitory executive function in the frontal lobe.