Neuropsychologia
-
Many patients with Parkinson's disease (PD) develop freezing of gait (FoG), which may manifest as a hesitation or "getting stuck" when they attempt to pass through a doorway. In two experiments, we asked whether FoG is associated with (1) a deficit in internal representation of one's body size with respect to a doorway and (2) a mismatch between imagined and actual walking times when passing through a doorway. ⋯ The equivalent passability judgments in PD subjects with and without FoG indicate that FoG is not specifically associated with a deficit in ability to internally represent space with reference to body size. However, the large difference in duration between actual and imagined walking through narrow doorways in subjects with FoG suggests that PD subjects with FoG did not know how much they would slow down to pass through narrow doorways. The observed discrepancy between imagined and actual walking times may point to a specific problem that contributes to the occurrence of FoG. These results also suggest that caution should be used when interpreting brain imaging results from locomotor imagery studies with PD subjects who have FoG.
-
Excitatory anodal transcranial direct current stimulation (A-tDCS) over the left dorsal prefrontal cortex (DPFC) has been shown to improve language production. The present study examined neurophysiological underpinnings of this effect. In a single-blinded within-subject design, we traced effects of A-tDCS compared to sham stimulation over the left DPFC using electrophysiological and behavioural correlates during overt picture naming. ⋯ Together, these findings demonstrate electrophysiological modulations induced by A-tDCS of the left DPFC. They suggest that A-tDCS is capable of enhancing neural processes during and after application. The present functional and oscillatory neural markers could detect positive effects of prefrontal A-tDCS, which could be of use in the neuro-rehabilitation of frontal language functions.
-
Two distinctly different maturational processes - cortical thinning and white matter maturation - take place in the brain as we mature from late childhood to adulthood. To what extent does each contribute to the development of complex cognitive functions like working memory? The independent and joint contributions of cortical thickness of regions of the left fronto-parietal network and the diffusion characteristics of the connecting pathway of the left superior longitudinal fasciculus (SLF) in accounting for verbal working memory performance were investigated, using a predefined regions of interest-approach. 108 healthy participants aged 8-19 years underwent MRI, including anatomical and diffusion tensor imaging (DTI), as well as cognitive testing using a digit span task. Radial diffusivity of the SLF, as well as cortical thickness of supramarginal gyrus and rostral middle frontal cortex, were negatively related to digit span forwards performance, independently of age. ⋯ A multi-modal analysis showed that cortical thickness and SLF microstructure were complementary in explaining working memory span. Furthermore, SLF microstructure and cortical thickness had different impact on working memory performance during the developmental period, suggesting a complex developmental interplay. The results indicate that cortical and white matter maturation each play unique roles in the development of working memory.
-
The current study investigated the relationship between bilingual language proficiency and onset of probable Alzheimer's disease (AD) in 44 Spanish-English bilinguals at the UCSD Alzheimer's Disease Research Center. Degree of bilingualism along a continuum was measured using Boston Naming Test (BNT) scores in each language. ⋯ These findings establish a specific connection between knowledge of two languages and delay of AD onset, and demonstrate that bilingual effects can be obscured by interactions between education and bilingualism, and by failure to obtain objective measures of bilingualism. More generally, these data support analogies between the effects of bilingualism and "cognitive reserve" and suggest an upper limit on the extent to which reserve can function to delay dementia.