Anesthesia and analgesia
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Anesthesia and analgesia · Dec 1985
Clinical Trial Controlled Clinical TrialIntravenous lidocaine as a suppressant of coughing during tracheal intubation.
Effects of intravenously administered lidocaine on cough suppression during tracheal intubation under general anesthesia were evaluated in two studies. In study 1, 100 patients received either a placebo or 0.5, 1.0, 1.5, or 2.0 mg/kg lidocaine intravenously 1 min before tracheal intubation. All visible coughs were classified as coughing. ⋯ The same criteria for determining whether a patient did or did not cough during tracheal intubation were used as in study 1. The incidence of coughing decreased significantly (P less than 0.01) when 2 mg/kg of lidocaine was injected intravenously between 1 and 5 min before our attempting intubation. Cough reflex was suppressed completely by plasma concentrations of lidocaine in excess of 3 micrograms/ml.
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The study was undertaken to evaluate the postoperative pain control ability of ketamine injected into the epidural space. We conclude that it produces potent postoperative analgesia without major respiratory depression or other side effects.