Anesthesia and analgesia
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Anesthesia and analgesia · Aug 1987
Randomized Controlled Trial Comparative Study Clinical TrialEpidural ketamine for postoperative pain relief after gynecologic operations: a double-blind study and comparison with epidural morphine.
This double-blind study evaluates whether ketamine given epidurally is effective for postoperative pain relief, and compares the effects of epidural ketamine with those of epidural morphine. Sixty-eight patients undergoing abdominal gynecologic surgery were randomly assigned into six groups (control; ketamine 4, 6, and 8 mg in saline; 6 mg in 10% glucose; morphine 3 mg). ⋯ Significantly, none of the patients in the morphine group needed additional analgesics within 24 hr, whereas 85% in the other five groups did. We conclude that ketamine administered epidurally is inadequate for postoperative pain relief after gynecologic operations.
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Anesthesia and analgesia · Aug 1987
Randomized Controlled Trial Comparative Study Clinical TrialNitrous oxide does not increase the incidence of nausea and vomiting after isoflurane anesthesia.
A total of 110 patients undergoing elective abdominal hysterectomy were anesthetized in random order with either isoflurane in nitrous oxide and oxygen or isoflurane in air and oxygen. Fentanyl was used as an adjunct to isoflurane in all patients, 0.05 mg every 45 min. ⋯ Patients who had had nausea or vomiting after previous anesthetics had nausea or vomiting significantly more frequently than patients who did not. It is concluded that nitrous oxide does not contribute to the occurrence of nausea or vomiting after isoflurane anesthesia for gynecologic laparotomies.