Anesthesia and analgesia
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Anesthesia and analgesia · Apr 1992
Randomized Controlled Trial Comparative Study Clinical TrialComparison of propofol versus ketamine for anesthesia in pediatric patients undergoing cardiac catheterization.
Intravenous propofol was compared with ketamine in 20 pediatric patients undergoing cardiac catheterization. The study patients were randomly assigned to treatment groups so that 10 patients received ketamine and 10 patients received propofol. The hemodynamic responses and recovery characteristics of the two groups were compared. ⋯ Time to full recovery (mean +/- SD) was significantly less in the propofol group (24 +/- 19 min vs 139 +/- 87 min, P less than 0.001). In the ketamine group only, significant correlations (P less than 0.05) included time to full recovery with duration of anesthetic (r = 0.71) and time to full recovery with total drug dose per kilogram (r = 0.82). The authors conclude that propofol anesthesia is a practical alternative for pediatric patients undergoing elective cardiac catheterization and may be preferable to ketamine because of the significantly shorter recovery time.
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Anesthesia and analgesia · Apr 1992
Randomized Controlled Trial Comparative Study Clinical TrialA comparative study of transdermal 10% lidocaine gel with and without glycyrrhetinic acid monohemiphthalate disodium for pain reduction at venous cannulation.
The clinical benefits of transdermal 10% lidocaine base gels with and without 3% glycyrrhetinic acid monohemiphthalate disodium (GAMHPh) for reduction of pain at venous cannulation were compared in a randomized, double-blind fashion in 24 surgical patients. After about 60 min of occlusive transdermal application, the mean pinprick pain score (1.3 +/- 1.5) in the GAMHPh group (n = 12), graded by noting the number of painful pinpricks out of five, was significantly less than that (2.5 +/- 1.7) in the control group (n = 12) (P less than 0.05). ⋯ Erythema observed in 8 of the 24 patients was the only adverse local reaction. Addition of 3% GAMHPh to the lidocaine gel is useful in promoting transdermal lidocaine absorption.
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Anesthesia and analgesia · Apr 1992
Complications occurring in the postanesthesia care unit: a survey.
To identify and quantitate complications occurring in the postanesthesia care unit (PACU), a prospective study evaluated 18,473 consecutive patients entering a PACU at a university teaching hospital. Using a standardized collection form, the incidence of intraoperative and PACU complications was determined. The combined PACU and intraoperative complication rate was 26.7%. ⋯ In patients experiencing a major cardiovascular complication, for example, variables associated with a greater risk of developing any PACU complications were ASA physical status (status II), duration of anesthesia (2-4 h), anesthetic technique, emergency procedures, and certain types of surgical procedures (orthopedic or abdominal). For patients admitted with a temperature of less than 35 degrees C the duration of the PACU stay was 152 +/- 46 min compared with 116 +/- 65 min for patients with a temperature greater than or equal to 36 degrees C (P less than 0.01). In conclusion, events occurring during the PACU period continue to be a source of patient morbidity.
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Anesthesia and analgesia · Apr 1992
Comparative StudyQuantification of the jet function of a jet stylet.
The concept and use of a jet stylet as an additional safety measure during tracheal extubation of patients in whom subsequent ventilation and/or reintubation of the trachea may be difficult has recently been described. If jet ventilation through a jet stylet could provide for effective gas exchange, it would allow additional time to assess the need for reintubation of the trachea. We determined the tidal volumes (measured by integrating a pneumotachograph flow signal) that 50-psi jet ventilation, at an inspiratory to expiratory time ratio of 1:1 (unit of time = 1 s), could deliver through small, medium, and large Sheridan tube exchangers into an in vitro lung model that had lung compliances of 50 and 30 mL/cm H2O (six experimental permutations). ⋯ Decreased lung compliance caused decreased VT and end-expiratory volume for all six experimental conditions. The largest VT and minute ventilation (VE) generated were 1680 mL and 51.6 L/min (large tube exchanger, high lung compliance) and the lowest VT and VE were 440 mL and 13.2 L/min (small tube exchanger, low lung compliance), respectively. These findings validate the term "jet stylet" for all three tube exchangers as even the smallest tube exchanger, coupled with a low lung compliance, can provide a VE consistent with total ventilatory support for most clinical situations.
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Anesthesia and analgesia · Apr 1992
Comparative StudyComparison of etomidate, ketamine, midazolam, propofol, and thiopental on function and metabolism of isolated hearts.
The authors examined direct myocardial and coronary vascular responses to the anesthetic induction agents etomidate, ketamine, midazolam, propofol, and thiopental and compared their effects on attenuating autoregulation of coronary flow as assessed by changes in oxygen supply/demand relationships. Spontaneous heart rate, atrioventricular conduction time during atrial pacing, left ventricular pressure (LVP), coronary flow (CF), percent oxygen extraction, oxygen delivery, and myocardial oxygen consumption (MVo2) were examined in 55 isolated guinea pig hearts divided into five groups of 11 each. Hearts were perfused at constant pressure with one of the drugs administered at steady-state concentrations increasing from 0.5 microM to 1 mM. ⋯ Between 100 microM and 1 mM, thiopental and ketamine did not increase CF but decreased MVo2 and percent oxygen extraction, whereas propofol maximally increased CF and decreased MVo2 and midazolam and etomidate had intermediate effects. These results indicate that on a molar basis, propofol, and less so midazolam and etomidate, depress cardiac function moderately more than thiopental and ketamine, and that propofol markedly attenuates autoregulation by causing coronary vasodilation. With doses used to induce anesthesia, propofol and thiopental appear to depress cardiac function more than ketamine or etomidate.