Anesthesia and analgesia
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Anesthesia and analgesia · Dec 1993
Randomized Controlled Trial Clinical TrialPain on injection of propofol: modification by nitroglycerin.
The effect of applying nitroglycerin or placebo ointment to the back of the hand before venipuncture and injection of propofol was investigated in 60 ASA physical status I unpremedicated women. Eighteen patients (67%) pretreated with nitroglycerin experienced no pain compared with 10 (33%) in the placebo group. ⋯ No patient had a headache or experienced postural hypotension. We conclude that nitroglycerin ointment applied to the back of the hand before injection reduces the incidence of painful injection with propofol.
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Anesthesia and analgesia · Dec 1993
Randomized Controlled Trial Comparative Study Clinical TrialIncremental dosing versus single-dose spinal anesthesia and hemodynamic stability.
We compared the hemodynamic stability after spinal anesthesia with two different dosing regimens in the elderly. Fifty patients, all older than 60 yr and scheduled for elective knee or hip surgery were assigned to two groups. After administration of 10 mL/kg of lactated Ringer's solution (RL) intravenously (i.v.) in the first group, we performed a continuous spinal anesthesia (CSA) by means of a 28-gauge catheter through which repetitive injections of 2.5-5 mg of plain bupivacaine 0.5% were given. ⋯ In the SS group more fluid was needed (792 vs 388 ml) than in the CSA group (P < 0.01). Moreover, more patients of the SS group (11 vs 4) required ephedrine (P < 0.05). We conclude that CSA produces reliable and predictable analgesia for lower limb surgery with less need for correction of hemodynamic changes compared to SS.
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Anesthesia and analgesia · Dec 1993
Comparative StudyPharmacokinetics and pharmacodynamics of rocuronium (Org 9426) in elderly surgical patients.
The effects of age on the pharmacokinetic and pharmacodynamic responses to rocuronium (Org 9426) were studied in 20 elderly (> 70 yr) and 20 younger control patients (< 60 yr) during N2O/O2, fentanyl anesthesia. The onset times were the same for both the elderly and younger control group, but the duration of action of rocuronium was significantly prolonged in the elderly patients. Elderly patients, when compared with the younger, also exhibited a significant decrease in plasma clearance (3.67 +/- 1.0 vs 5.03 +/- 1.5 mL.kg-1.min-1, mean +/- SD) and volume of distribution (399 +/- 122 vs 553 +/- 279 mL/kg, mean +/- SD). ⋯ The differences in action of rocuronium between the elderly and younger groups can be fully explained by the observed differences in the distribution and elimination of rocuronium between the two groups. The decreased total body water and decreased liver mass which normally accompany aging are likely explanations for the pharmacokinetic changes found in the elderly in this study. We conclude that the action of rocuronium is prolonged in patients aged more than 70 yr because of decreased elimination of the drug.
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Anesthesia and analgesia · Dec 1993
Comparative StudyUse of the self-inflating bulb for detecting esophageal intubation after "esophageal ventilation".
This present investigation tests the efficacy of the self-inflating bulb for detecting esophageal intubation after intentional "esophageal ventilation" to mimic gastric insufflation after bag-and-mask ventilation. In 72 anesthetized patients, the trachea and esophagus were intubated with identical tubes. The efficacy of the bulb was tested by a second anesthesiologist before and after the delivery of three breaths at a tidal volume of 300-350 mL each. ⋯ In all patients, the second anesthesiologist reported no reinflation of the bulbs when connected to esophageally placed tubes and instantaneous reinflation when connected to tracheally placed tubes, thus correctly identifying the location of each tube. The mean negative pressure generated when compressed bulbs were connected to esophageally placed tubes was 55.4 +/- 1.2 mm Hg before esophageal ventilation and 59.0 +/- 0.68 mm Hg after esophageal ventilation. We conclude that insufflation of the stomach as a result of esophageal ventilation, to the extent demonstrated in this study, does not interfere with the effectiveness of the bulb in differentiating esophageal from tracheal intubation.
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Anesthesia and analgesia · Dec 1993
Airway management for patients with penetrating neck trauma: a retrospective study.
Airway management in patients with penetrating neck trauma is controversial. We reviewed the records of 107 patients with penetrating neck trauma from 1989 through 1991 for primary intubation technique, mechanism of injury, zone of injury, and structures injured. Six patients (6%) received a surgical airway as the primary choice, 89 (83%) had direct laryngoscopies after rapid sequence induction of anesthesia, eight (7%) had awake fiberoptic bronchoscopies, and four (4%) had awake blind nasotracheal intubation. ⋯ A second patient died as a result of hemorrhage not related to airway management. Success rates were not statistically different with any of the four airway management techniques chosen primarily. However, the one death in the awake nasal intubation group and the technical and time constraints of fiberoptic intubation cause us to prefer rapid sequence induction of anesthesia with direct laryngoscopy or a primary surgical airway in patients with penetrating neck trauma who need an emergency airway.