Anesthesia and analgesia
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Anesthesia and analgesia · Dec 2000
Comparative StudyThe comparative toxicity of ropivacaine and bupivacaine at equipotent doses in rats.
We compared the toxicity of systemic local anesthetics bupivacaine and ropivacaine administered at equivalent and equipotent doses. In the first experiments, 18 male Wistar rats were anesthetized with thiopental and maintained under positive controlled ventilation. Electrocardiogram, electroencephalogram, and invasive arterial blood pressure were continuously recorded. ⋯ In awake rats, all the animals intoxicated by ropivacaine easily recovered. In the bupivacaine group, two animals required cardiopulmonary resuscitation before any seizure activity could be detected, and only three rats survived. We conclude that, in the model used, ropivacaine, even at an equipotent dose, is less toxic than bupivacaine.
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Anesthesia and analgesia · Dec 2000
Comparative Study Clinical TrialComparing Doppler ultrasonography and cerebral oximetry as indicators for shunting in carotid endarterectomy.
To determine the thresholds of selective shunting in carotid endarterectomy during general anesthesia, we compared transcranial Doppler ultrasonography and cerebral oximetry (RSO2). During carotid cross-clamping, RSO2 and mean blood flow velocity in the middle cerebral artery (Vm,mca) was simultaneously monitored in 55 of 59 patients. A relative decrease in Vm,mca to <20% of preclamp velocity was the indication for selective shunting. ⋯ Transcranial Doppler ultrasonography identified patients at risk for ischemia more accurately than RSO2. Relying on RSO2 alone would increase the number of unnecessary shunts because of the low specificity. Accepting higher decreases in RSO2 does not appear reasonable because it bears the risk of a low sensitivity.
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Anesthesia and analgesia · Dec 2000
Comparative Study Clinical TrialBalloon versus conventional laryngoscopy: a comparison of laryngoscopic findings and intubation difficulty.
We compared laryngeal aperture (LA) exposure and endotracheal intubation difficulty scale (IDS) scores between balloon-assisted and conventional laryngoscopy. Thirty-two anesthetized and paralyzed elective surgery patients underwent laryngoscopy with a standard number 4 and a modified number 4 curved blade carrying a 6F Fogarty catheter. The balloon laryngoscopy technique included modified blade tip insertion into the vallecula, Fogarty catheter balloon inflation with 2 mL of air, and blade elevation until LA exposure maximization. ⋯ The data from 27 patients were analyzed. The exposed LA areas were significantly larger with balloon laryngoscopy than conventional (median, interquartile range: 0.94, 0.65-1.80 cm(2) vs. 0.52, 0.39-1.46 cm(2) respectively) (P = 0.027), and the IDS scores lesser (median, interquartile range: 0, 0-1 vs. 1, 0-2 respectively) (P = 0.012). We concluded that balloon laryngoscopy facilitates elective airway management.
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Anesthesia and analgesia · Dec 2000
Case ReportsAnesthesia for fetoscopic fetal surgery: twin reverse arterial perfusion sequence and twin-twin transfusions syndrome.
Twin reversed arterial perfusion sequence and twin-twin transfusion syndrome can be managed by fetoscopic fetal surgery. It is important to consider the fetal, uteroplacental, and maternal issues when choosing an anesthetic technique. We report on three patients with differing anesthetic issues using fetoscopic surgery for umbilical cord coagulation.
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Anesthesia and analgesia · Dec 2000
Randomized Controlled Trial Clinical TrialThe analgesic efficacy of patient-controlled ropivacaine instillation after Cesarean delivery.
To assess the efficacy and safety of wound instillation of ropivacaine, when administered via a patient-controlled elastometric pump, 50 term parturients undergoing cesarean delivery were enrolled into this prospective, placebo-controlled, double-blinded study. In all cases, a standard spinal anesthetic was administered. After the surgery, a multihole 20-gauge epidural catheter (B. ⋯ However, blood ropivacaine accumulation was noted. All patients stated that the elastometric pump was easy to use. Ropivacaine wound instillation via an elastometric pump is a simple technique that provides safe and effective analgesia after cesarean delivery.