Anesthesia and analgesia
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Anesthesia and analgesia · Dec 2004
Letter Comparative StudyPostoperative analgesia and recovery after open and laparoscopic prostatectomy.
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Anesthesia and analgesia · Dec 2004
Potent activation of the human tandem pore domain K channel TRESK with clinical concentrations of volatile anesthetics.
The tandem pore domain K channel family mediates background K currents present in excitable cells. Currents passed by certain members of the family are enhanced by volatile anesthetics, thus suggesting a novel mechanism of anesthesia. The newest member of the family, termed TRESK (TWIK [tandem pore domain weak inward rectifying channel]-related spinal cord K channel), has not been studied for anesthetic sensitivity. ⋯ Amide and ester local anesthetics inhibit TRESK in a concentration-dependent manner but at concentrations generally larger than those that inhibit other tandem pore domain K channels. We also determined that TRESK is found not only in spinal cord, but also in human brain RNA. These results identify TRESK as a target of volatile anesthetics and suggest a role for this background K channel in mediating the effects of inhaled anesthetics in the central nervous system.