Anesthesia and analgesia
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Anesthesia and analgesia · Jul 2010
Inhaled carbon monoxide prevents acute kidney injury in pigs after cardiopulmonary bypass by inducing a heat shock response.
Cardiopulmonary bypass (CPB) may be associated with acute kidney injury (AKI). Inhaled carbon monoxide (CO) is cyto- and organ-protective. We hypothesized that pretreatment with inhaled CO prevents CPB-associated AKI. ⋯ CO treatment before CPB was associated with evidence of renoprotection, demonstrated by fewer histological injuries and decreased cystatin C concentrations. The findings that the antiinflammatory and antiapoptotic effects of CO were accompanied by activation of HSP-70, which in turn were reversed by quercetin, suggest that renoprotection by pretreatment with inhaled CO before CPB is mediated by activation of the renal heat shock response.
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Anesthesia and analgesia · Jul 2010
Editorial CommentPRO: accumulating evidence for an outrageous claim.
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Anesthesia and analgesia · Jul 2010
Editorial CommentNeuromuscular block: views from the Western pacific.