Anesthesia and analgesia
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Anesthesia and analgesia · Aug 2014
Review Meta AnalysisNicotine for Postoperative Analgesia: A Systematic Review and Meta-Analysis.
Peri-operative nicotine very slightly reduces opioid consumption in non-smokers but not pain scores — and increases the incidence of post-op nausea.
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Anesthesia and analgesia · Aug 2014
Randomized Controlled Trial Comparative StudyAccuracy of the Composite Variability Index as a Measure of the Balance Between Nociception and Antinociception During Anesthesia.
The Composite Variability Index (CVI), derived from the electroencephalogram, was developed to assess the antinociception-nociception balance, whereas the Bispectral Index (BIS) was developed to assess the hypnotic state during anesthesia. We studied the relationships between these indices, level of hypnosis (BIS level), and antinociception (predicted remifentanil effect-site concentrations, CeREMI) before and after stimulation. Also, we measured their association with movement in response to a noxious stimulus. ⋯ CVI appears to correlate with somatic responses to noxious stimuli. However, unstimulated CVI depends more on hypnotic drug effect than on opioid concentration.
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Anesthesia and analgesia · Aug 2014
Inflammatory Pain May Induce Cognitive Impairment Through an Interlukin-6-Dependent and Postsynaptic Density-95-Associated Mechanism.
Pain might be associated with cognitive impairment in humans. However, the characterization of such effects in a preclinical model and the investigation of the underlying mechanisms remain largely to be determined. We therefore sought to establish a system to determine the effect of pain on cognitive function in mice. ⋯ These results suggest that pain induced by CFA injection might increase interleukin-6 levels and decrease PSD-95 levels in the cortex, but not hippocampus of mice, leading to hippocampus-independent cognitive impairment in mice. These findings call for further investigation to determine the role of pain in cognitive function.
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Anesthesia and analgesia · Aug 2014
Observational StudyEpidural Labor Analgesia Is Associated with a Decreased Risk of Postpartum Depression: A Prospective Cohort Study.
Labour epidural analgesia may be associated with a lower incidence of post-natal depression.
pearl