Anesthesia and analgesia
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Anesthesia and analgesia · Oct 2015
Randomized Controlled TrialPreparing Parents to Be Present for Their Child's Anesthesia Induction: A Randomized Controlled Trial.
The purpose of this study is to compare the effectiveness of a brief preparation intervention for parental presence during induction of anesthesia (PPIA preparation) with a PPIA with standard preparation (PPIA standard). ⋯ A brief, video-based intervention aimed at preparing parents to be present for their child's anesthesia induction was not successful in reducing the children's preoperative anxiety. However, it is unclear whether parents included in this study actually performed as instructed in the intervention to reduce their children's anxiety. Future research should monitor parent behavior and support parental performance to reduce their children's preoperative anxiety.
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Anesthesia and analgesia · Oct 2015
A Multimodal Intervention Improves Post-Anesthesia Care Unit Handovers.
Failures of communication are a major contributor to perioperative adverse events. Transitions of care may be particularly vulnerable. We sought to improve postoperative handovers. ⋯ A multimodal intervention substantially improved interprofessional PACU handovers, including those by clinicians who had not undergone formal simulation training. An effect appeared to be present >3 years later.
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Anesthesia and analgesia · Oct 2015
A Bolus and Bolus Followed by Infusion Study of AZD3043, an Investigational Intravenous Drug for Sedation and Anesthesia: Safety and Pharmacodynamics in Healthy Male and Female Volunteers.
AZD3043 (THRX-918661) is an investigational phenylpropanoid sedative/anesthetic that is rapidly metabolized by esterases in blood and liver. In the first-in-man study, a 30-minute constant IV infusion of AZD3043 induced anesthesia without major safety or tolerability concerns and with rapid recovery characteristics. ⋯ AZD3043 provided rapid recovery from anesthesia with maintained ventilation. Further studies are warranted in a clinical setting.