Anesthesia and analgesia
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Anesthesia and analgesia · Oct 2015
Contralateral Hyperalgesia from Injection of Endothelin-1 into the Ipsilateral Paw Requires Efferent Conduction into the Contralateral Paw.
Contralateral hyperalgesia, occurring after unilateral injury, is usually explained by central sensitization in spinal cord and brain. We previously reported that injection of endothelin-1 (ET-1) into one rat hindpaw induces prolonged mechanical and chemical sensitization of the contralateral hindpaw. Here, we examined the role of contralateral efferent activity in this process. ⋯ These results show that efferent transmission through the contralateral innervation into the paw is necessary for contralateral sensitization by ET-1, suggesting that the release of substances by distal nerve endings is involved. The release of substances in the periphery is essential for contralateral sensitization by ET-1 and may also contribute to secondary hyperalgesia, occurring at loci distant from the primary injury, that occurs after surgery or nerve damage.
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Anesthesia and analgesia · Oct 2015
Editorial Comparative StudyDavid (Propofol Wannabes) Versus Goliath (Propofol): AZD-3043 Goes Up Against the Giant!
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Anesthesia and analgesia · Oct 2015
Editorial"You Live Life Going Forwards and Understand It Looking Backwards!" The Sixtieth Anniversary of the World Federation of Societies of Anaesthesiologists: 60 Years of Cooperation Between the International Anesthesia Research Society and the World Federation of Societies of Anaesthesiologists.