The Annals of thoracic surgery
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Randomized Controlled Trial Clinical Trial
Endothelin-1 and neutrophil activation during heparin-coated cardiopulmonary bypass.
Heparin-coated circuits attenuate the systemic inflammatory response to cardiopulmonary bypass. The present study compares two different heparin coatings in terms of the release of endothelin-1 and neutrophil glycoproteins. ⋯ The plasma levels of endothelin-1, lactoferrin, and myeloperoxidase increase during cardiopulmonary bypass in coronary artery bypass grafting, but this has no clinical side effects in low-risk patients. The increase is attenuated using heparin-coated extracorporeal circuits, and then more effectively by Carmeda BioActive Surface than by Duraflo II.
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Randomized Controlled Trial Comparative Study Clinical Trial
Effects of diltiazem versus digoxin on dysrhythmias and cardiac function after pneumonectomy.
This prospective study was designed to determine whether diltiazem is superior to digoxin for the prophylaxis of supraventricular dysrhythmias (SVD) after pneumonectomy or extrapleural pneumonectomy (EPP) and to assess the influence of these drugs on perioperative cardiac function. ⋯ Diltiazem was both safe and more effective than digoxin in reducing the overall incidence of SVD after standard or intrapericardial pneumonectomy. Digoxin therapy had no effect on the incidence of postoperative SVD and is not recommended for prophylaxis of SVD. Dysrhythmias after pneumonectomy or EPP occur in older patients and are associated with a greater length of hospital stay.
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We studied whether negative inlet pressure created by a centrifugal pump during extracorporeal membrane oxygenation damages blood. ⋯ There were strong indications that reduction of negative pump inlet pressure with the servo regulator prevented hemolysis and kidney damage.
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Randomized Controlled Trial Comparative Study Clinical Trial
Normothermic retrograde blood cardioplegia with or without preceding ischemic preconditioning.
Preconditioning has been suggested as the most powerful mechanism of myocardial protection against prolonged ischemia. However, whether preconditioning offers additional benefits over cardioplegia during coronary artery bypass grafting is not known. ⋯ The results show that a 5-minute preconditioning ischemia does not offer any additional benefits over normothermic retrograde blood cardioplegia during coronary artery bypass grafting.
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Randomized Controlled Trial Clinical Trial
Cardiac enzymes and autotransfusion of shed mediastinal blood after myocardial revascularization.
Autotransfusion of shed mediastinal blood reduces blood requirement after coronary artery bypass grafting. Recently, two nonrandomized trials indicated that autotransfusion elevates the levels of cardiac enzymes after cardiac operations. ⋯ Postoperative autotransfusion of shed mediastinal blood causes elevation of cardiac enzyme levels after coronary artery bypass grafting.