Atherosclerosis
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Effects of potent free radical scavenger, edaravone, on oxidative stress-induced endothelial damage and early atherosclerosis were investigated using animal models and cultured cells. ⋯ These results suggest that edaravone may be a useful therapeutic tool for early atherosclerosis, pending the clinical efficacy.
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Comparative Study
Mitral annular calcification predicts mortality and coronary artery disease in end stage renal disease.
We sought to determine whether mitral annular calcification (MAC) predicts mortality and cardiac disease in a group of renal transplant candidates. ⋯ MAC is associated with increased mortality and significant CAD in ESRD. These patients have increased LV cavity size, poorer LV systolic function, higher LV filling pressures compared to patients without MAC.
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Comment Letter Clinical Trial
Beneficial effect of statins in multiple sclerosis: is it dose-dependent?