Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen
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Following reperfusion of preserved organ grafts, various pathomechanisms are activated that may impair graft function and viability beyond ischemic damage. This so-called reperfusion injury includes generation of oxygen radicals, recruitment and activation of circulating inflammatory cells, and liberation of numerous mediators acting both locally and systemically. Alterations in microvascular perfusion are of central importance where further graft damage is concerned. The present review covers the current knowledge about the underlying mechanisms, the organ-specific application in the clinical setting, and the possible immunological consequences of reperfusion injury.
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Clinical Trial
[Surgical treatment of ankle joint fractures with biodegradable screws and plates of poly-l-lactide].
In a first clinical protocol 19 ankle fractures have been fixed by plates and screws made of biodegradable polylactic acid. Fracture confirmation was achieved within 6 weeks. 52% of our patients demonstrated an aseptic soft tissue problem caused by delayed clearance of the degrading polylactide particles. ⋯ These results emphasize that the application of plates and screws of polylactic acid is acceptable for fixation of ankle fractures. Soft tissue inflammatory reactions can be avoided by using volume reduced implants.