Wiener klinische Wochenschrift
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Wien. Klin. Wochenschr. · Jan 2003
Interaction between angiotensin-converting enzyme genotype and glycaemic control influences lipoprotein levels in type 2 diabetes mellitus.
To evaluate the influence of the angiotensin-converting enzyme (ACE) insertion/deletion (I/D) polymorphism on lipid levels in patients with Type 2 diabetes. ⋯ The present study showed that the interaction between the DD genotype of angiotensin-converting enzyme and chronic hyperglycaemia (expressed by HbA1c level) is related to higher plasma levels of atherogenic lipoproteins, such as apoB and cholesterol, in patients with Type 2 diabetes.
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Wien. Klin. Wochenschr. · Jan 2003
Comparative Study Clinical TrialComparison of the in-vitro activity of amodiaquine and its main metabolite, monodesethyl-amodiaquine, in Plasmodium falciparum.
After its rehabilitation for therapeutic use in uncomplicated falciparum malaria, there is renewed interest in amodiaquine. After oral administration, the drug undergoes rapid metabolism to monodesethyl-amodiaquine, and in patients with normal hepatic function the parent drug usually becomes undetectable within a few hours. The main antimalarial activity is therefore mainly due to the metabolite. ⋯ Differences between regression slopes and effective concentrations were well below statistical significance. Both compounds showed highly significant activity correlation. These findings suggest that the sensitivity of Plasmodium falciparum to amodiaquine closely reflects its sensitivity to monodesethyl-amodiaquine.
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Wien. Klin. Wochenschr. · Jan 2003
[Must we expect an epidemic of measles in the near future in Southern Tyrol?].
Measles, Mumps and Rubella (MMR) vaccination is recommended in Italy. A country-wide study of the 1996 birth cohort revealed that coverage with MMR vaccine in the autonomous Province of Bolzano is the third lowest in Italy (after Campania and Calabria). The aim of the study was to evaluate the situation regarding measles in order to plan and implement necessary strategies. ⋯ The total amount of direct costs was estimated to be 386,437.72 Euros. Due to low vaccine coverage rates, especially in rural areas, and the ongoing circulation of the measles virus in the population, it is likely that an extensive measles epidemic will occur in the near future, resulting in evitable suffering of patients and extensive costs for the public health system. Only an effective immunization campaign will be able to prevent a future epidemic.
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Wien. Klin. Wochenschr. · Jan 2003
Review[New insights on the effects of hormone replacement therapy on the breast tissue and the orgnaism].
Within the last fifteen to twenty years extensive discussions were held about advantages and disadvantages of postmenopausal hormone replacement therapy. Basing on recent data from prospectively randomized studies the long-term application of a combined estrogen-gestagen therapy for general prophylaxis cannot be recommended. Ongoing studies are expected to provide sufficient data to determine regimens for the prevention of osteoporosis, development of cancer, and cardiovascular diseases.