Wiener klinische Wochenschrift
-
Wien. Klin. Wochenschr. · Sep 2020
Correction to: Knock-on effect of periodontitis to the pathogenesis of Alzheimer's disease?
The original version of this article unfortunately contained a mistake. There was an error in Fig. 2. ⋯ We apologize for the mistake. The correct Fig. 2 is given ….
-
Wien. Klin. Wochenschr. · Sep 2020
Knock-on effect of periodontitis to the pathogenesis of Alzheimer's disease?
Alzheimer's disease has chronic inflammatory components, which can be enhanced by systemic immune activation resulting in inflammation or vice versa. There is growing evidence that chronic periodontitis drives systemic inflammation and finally Alzheimer's disease. Thus, a link might exist between oral pathogens and Alzheimer's disease. This may be of special significance as there is an age-related incidence of chronic periodontitis. ⋯ Data indicate a possible association of specific periodontal pathogens with cognitive impairment, Treponema denticola and Tannerella forsytia may alter the host immune response in Alzheimer's disease. Albeit still preliminary, findings of the study may point to a possible role of an altered salivary microbiome as a causal link between chronic periodontitis and cognitive impairment in Alzheimer's disease.