Wiener klinische Wochenschrift
-
Wien. Klin. Wochenschr. · Mar 2021
Diagnosis of hepatic nuclear factor 1A monogenic diabetes mellitus (HNF1A-MODY) impacts antihyperglycemic treatment.
Monogenic mutations of the hepatocyte nuclear factor 1 homeobox A maturity onset diabetes of the young (HNF1A-MODY) is characterized by early onset, typically before the age of 25 years. Patients are often not clinically recognized; however, the identification of HNF1A-MODY patients is crucial because they require different antihyperglycemic medical treatment than patients with type 1 or type 2 diabetes mellitus. We describe two adult patients with monogenic diabetes, both identified as HNF1A-MODY, genetically c.815G>A, p. ⋯ They were misdiagnosed as having type 1 diabetes mellitus, and consequently, initiating insulin therapy led to hypoglycemia and unstable blood glucose control. Usually, sulfonylureas represent the basis of antidiabetic treatment in patients with HNF1A-MODY; however, all medical personnel involved in diabetes care should be aware of monogenic diabetes mellitus and the possibilities for genetic testing. The patients observed have shown the necessity of the identification and appropriate genetic diagnosis of HNF1A-MODY in order to discontinue insulin therapy and to initiate adjusted diabetes management.
-
Wien. Klin. Wochenschr. · Mar 2021
Review Meta AnalysisPrevalence of neuropathy in patients with type 2 diabetes in Iran : A systematic review and meta-analysis.
Diabetic neuropathy is one of the most common complications of diabetes, which leads to amputation and significant disability in patients. Studies conducted in this field show different prevalences and inconsistencies in the country. This study attempts to determine the overall prevalence of neuropathy in patients with type 2 diabetes in Iran with a meta-analysis. ⋯ Considering the high prevalence of neuropathy in patients with type 2 diabetes in the country, it is essential that health policy makers take effective measures to reduce this disease in diabetes patients.
-
Wien. Klin. Wochenschr. · Mar 2021
Incidence of thyroid disorders in the second decade of adequate iodine supply in Slovenia.
The incidence of thyroid disorders importantly depends on iodine supply and may change over time. There are only a few data available regarding the change in the incidence of thyroid disorders following the increase in iodine supply. Therefore, the aim of this study was to establish the incidence of thyroid disorders in the second decade of adequate iodine supply in Slovenia. ⋯ In the second decade of adequate iodine supply in Slovenia, we established a similar or even a lower incidence of most thyroid diseases in the observed 4 years with the exception of Hashimoto's thyroiditis.
-
Wien. Klin. Wochenschr. · Mar 2021
Silicone soft socket system for the treatment of geriatic transtibial amputees.
Outfitting geriatric amputees with a suitable prosthesis is a demanding task. The aim of this study was to determine the effect of prostheses outfitted with a silicone suspension interface system on a large group of transtibial amputees regarding walking distance, satisfaction of use and duration of daily use. ⋯ Geriatric transtibial amputees fitted with prostheses attached via a silicone suction socket system showed significant improvements in walking distances and a high rate of satisfaction with the device. There were no statistically significant gender-specific differences among users of the ICEROSS system.