Wiener klinische Wochenschrift
-
Wien. Klin. Wochenschr. · Sep 2000
p53 polymorphism at codon 72--does it constitute a risk for squamous intraepithelial lesions and invasive cancer of the cervix in Central Europeans?
Polymorphisms of the tumour suppresser gene p53 especially at codon 72 are suspected to be associated with an increased risk for malignant transformation. In invasive cervical cancer, the arginine form of the p53 gene is estimated to be more susceptible to degradation mediated by tumour-associated human papilloma viruses (HPV) than the proline form. ⋯ In conformity with other study groups, our findings do not support the hypothesis that the p53 polymorphism at codon 72 is important in determining an increased risk of developing HPV-associated SIL or invasive cervical cancer in Central Europeans.
-
Wien. Klin. Wochenschr. · Sep 2000
Comparative StudyHybrid capture based human papillomavirus typing in cervical screening compared to cytology and histology.
Cervical cancer is frequently associated with infection from various types of human papillomavirus (HPV) with high a oncogenic potential (high-risk types). Commercial systems for HPV typing are available, but the question as to when HPV typing should be performed has not yet been solved. ⋯ HC appears to be a useful system to triage women with PAP III or IIID and to detect patients with residual HPV infection after conization. However, because of high costs and no significant increase in the sensitivity of cytology, the use of HPV typing in routine cervical screening cannot be recommended in countries with opportunistic annual cytological screening.
-
Wien. Klin. Wochenschr. · Sep 2000
Biography Historical ArticleGiovanni Alessandro Brambilla (1728-1800) and the Imperial Infantry Regiment #22 ("Lacy"). On occasion of the bicentennial of his death.
Giovanni Alessandro Brambilia (1728-1800) was the Chief Surgeon of the Imperial Austrian Army and the first director of the newly founded medico-surgical academy in Vienna (1785). He died in Padua in late July 1800 (29th?), en route from his estate in Lombardy to Vienna, and the chiostro della magnolia in the Santo displays a memorial plaque commemorating his demise. On account of his merits for the education of (military) surgeons and the development of surgery in Austria, this short article shall serve to briefly recall his life and related facts.
-
Wien. Klin. Wochenschr. · Aug 2000
Case ReportsSmall vessel thrombosis without major thrombotic events in systemic lupus erythematosus patients with antiphospholipid syndrome.
Antiphospholipid syndrome has been defined by the presence of antiphospholipid antibodies or lupus anticoagulant in association with certain clinical events, including recurrent arterial or venous thromboses and recurrent fetal loss. It comprises two separate clinical entities: simple, characterized by large vessel occlusions, and catastrophic, with multiple occlusive events predominantly affecting small vessels. ⋯ Only postmortem histopathological examination revealed microangiopathic thrombotic changes in different organs, which were clinically silent in early stages of the disease and misinterpreted later in its course because of a peculiar clinical picture. All patients presented features of catastrophic antiphospholipid syndrome in the final stage of the disease.
-
Wien. Klin. Wochenschr. · Jul 2000
Case ReportsSuccessful use of continuous intravenous prostacyclin in a patient with severe portopulmonary hypertension.
Portopulmonary hypertension, defined by a mean pulmonary artery pressure > 25 mm Hg in the presence of normal pulmonary capillary wedge pressure and portal hypertension, is a known complication of end-stage liver disease that has been associated with high morbidity and mortality at the time of liver transplantation. ⋯ In this adult patient suffering from end-stage liver disease and portopulmonary hypertension, administration of continuous intravenous epoprostenol resulted in significant reduction of pulmonary hypertension and therefore in acceptance for orthotopic liver transplantation. Utilisation of this new therapeutic strategy might be a helpful pharmacological tool for patients with portopulmonary hypertension to make them acceptable for orthotopic liver transplantation.