Wiener klinische Wochenschrift
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Wien. Klin. Wochenschr. · Apr 2000
Clinical TrialIntra- and interindividual reproducibility of heart rate variations in the tilt-table test.
Various methods are used for the routine diagnosis of autonomic regulation disorders. The evaluation of blood pressure and heart rate response during active orthostasis together with assessment of the 30/15-ratio (Ewing's ratio) was proven to be a valid method. One main disadvantage of these tests is their dependence on the active cooperation of the patient. ⋯ However, all subjects showed considerable variations in heart rate response within the 10 tilting manoeuvres. A reliable quotient comparable with the 30/15 ratio (Ewing's ratio) in active orthostasis was not seen. Based on these results, we conclude that the initial heart rate response in the tilt-table test is not suitable for routine diagnosis of autonomic regulation disorders, since it is not sufficiently reproducible in healthy individuals.
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Management of the difficult airway has gained increasing interest, because hypoxia is one of the leading causes of death and of severe neurological sequelae related to anesthesia or resuscitation. The difficult airway algorithm of the American Society of Anesthesiologists as well as the guidelines of the European Resuscitation Council provide recommendations for the prevention of difficulties in tracheal intubation and/or mask ventilation. Especially preoperative patient evaluation is of major importance. ⋯ If problems in intubating the trachea are encountered after induction of anesthesia and mask ventilation is adequate, one must call for help and decide rapidly whether to awaken the patient or to proceed with alternative intubation techniques (e.g. different laryngoscope blades, flexible fiberoptic scope or other fiberoptic techniques, lighted wand, retrograde intubation or surgical airway). In the potentially life-threatening "cannot intubate--cannot ventilate" situation either transtracheal jet ventilation, laryngeal mask airway, the esophageal-tracheal Combitube or a surgical airway have to be performed or have to be inserted immediately. These alternative methods have to be appropriately taught and--as far as possible--to be trained under routine conditions in order to master emergency situations.
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Wien. Klin. Wochenschr. · Feb 2000
Case ReportsA case of pseudothrombocytopenia after infusion of abciximab in vivo and anticoagulant-independent platelet clumping after rechallenge with abciximab in vitro.
A 45-year old man was treated for unstable angina pectoris with percutaneous transluminal angioplasty and stenting of his left anterior descending coronary artery. The procedure was followed by infusion of abciximab. The patient's automated platelet count in an EDTA-anticoagulated blood sample at admission to the hospital was normal, but dropped to 5 x 10(9)/l three hours after the procedure. ⋯ At follow-up visits four months and one year after discharge from hospital, the patient's blood samples were anticoagulated with three different anticoagulants: EDTA, citrate and heparin. The platelet count was normal in all three samples but after mixing with abciximab in vitro it dropped profoundly due to platelet clumping, regardless of the choice of the anticoagulant. Our report raises two points: (a) one needs to consider the possibility of pseudothrombocytopenia in a patient with a low automated platelet count after infusion of abciximab but without signs of bleeding, and (b) the in vitro results suggest that our patient who had initially responded to abciximab with pseudothrombocytopenia could develop true thrombocytopenia after repeated exposure.
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Wien. Klin. Wochenschr. · Feb 2000
Letter Biography Historical Article[Comments on the Special Issue of the Wiener klinische Wochenschrift on the Vienna Anatomical Science, issue 18, 1999].
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Wien. Klin. Wochenschr. · Jan 2000
Review[Informed consent and responsibility for patient education in oncology. Review of Austrian and German jurisprudence].
Informed consent is currently an ethical, medical and legal requirement. Increasing public discussion concerning real or supposed malpractice has caused patients to adopt a critical attitude and has caused courts to increasingly demand informed consent for patients. ⋯ In addition, the law has failed to establish explicit guidelines for physicians. We review the elements of informed consent based on current Austrian and German jurisdiction in the particular field of oncology and summarise the legal and medical realities with the aim of delineating specific criteria for decision making.