Wiener klinische Wochenschrift
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Wien. Klin. Wochenschr. · Mar 1985
[Localization of functionally important areas of the regulator protein factor H using monoclonal antibodies].
Four monoclonal antibodies to the control protein of the complement system, factor H, were used to try to localize functionally important domains on the molecule. Attempts to inhibit the interaction of C3b and H in ELISA and agglutination assays by means of these monoclonal antibodies showed that two of them, namely MAH 1 and MAH 2, recognized an epitope in close proximity to the binding site for C3b on H. ⋯ The cofactor function of H with respect to C3b inactivator was inhibited by the same monoclonal antibodies which interfered with the binding of H to C3b. Since MAH 1, MAH 2, MAH 3 and MAH 4 all bind to the same tryptic 38 KD fragment of H, the binding site for C3b on H, as well as the cofactor activity seem to reside on this fragment.
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Although the phrase "no suicide without depression" may not be quite correct in this extreme wording, it must be stressed that the connection between depression and suicide is close and that the contribution of depression towards suicide is very large. The task of the examining physician is twofold. In the first place he has to judge from the phenomenological-psychopathological point of view to which extent the patient shows signs of the so-called "pre-suicidal syndrome", consisting of multi-dimensional narrowing in, inhibited and self-directed aggression, and increasing suicidal fantasies. ⋯ Endogenous depression, senile depression and neurotic depression have to be taken into consideration and the extent of the risk of suicide depends, not least, on the type of depression. As to therapy, neurotic depression requires psychotherapy, senile depression calls for socio-therapeutic measures and endogenous depression necessitates the administration of antidepressives. In all cases, however, the foundation for successful therapy rests on the achievement of a harmonious and genuine doctor-patient relationship.
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Wien. Klin. Wochenschr. · Feb 1985
[Biologico-pharmacologically oriented methods of treating depression with special reference to the state of medical practice].
Following a discussion of the diagnostic preconditions that are essential to any treatment of depression, this paper deals with the biologically-based therapies that recommend themselves in psychotherapy. Of chief interest here are the pharmacotherapeutic possibilities and above all the indications of the various antidepressants - many of them new - which are listed together with their German, Austrian and Swiss brand names in Table 8. ⋯ The main types of chronobiological therapy discussed are sleep deprivation and the use of light in the treatment of depression. Finally, there is a brief outline of shock therapy; for non-medical reasons, this no longer plays an important role today, but is nevertheless an extremely effective method of treating depression.
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Wien. Klin. Wochenschr. · Jan 1985
Case Reports[1st case of AIDS in Salzburg. Important diagnostic hint by determination of neopterin].
This case report describes the first case of AIDS in Salzburg. The patient belonged to the male homosexual risk group. ⋯ The diagnosis of AIDS was corroborated by highly elevated urinary neopterin levels. Despite treatment with antibiotics the patient died within 5 weeks due to cardiorespiratory insufficiency.
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Wien. Klin. Wochenschr. · Nov 1984
Randomized Controlled Trial Clinical Trial[Effect of nootropic drugs on normal and disturbed sleep of the elderly: controlled studies with pyridoxilate and street noise].
The effect of the nootropic drug, piridoxilate on normal and on exogenously (by traffic noise) disturbed sleep and awakening quality was investigated in a double-blind placebo-controlled study. 10 elderly subjects with a mean age of 62 years spent 13 nights in the sleep laboratory: 2 adaptation nights, 1 baseline night, 3 drug nights (placebo, 300 and 600 mg piridoxilate), as well as 2 drug nights with nocturnal traffic noise (placebo and 600 mg piridoxilate) and the subsequent wash-out nights. Polysomnographic recordings (including EEG, EMG and EOG) were carried out between 10:30 p.m. and 6.00 a.m. Traffic noise was pre-recorded at a busy Viennese street and presented continuously by a loudspeaker with a sound pressure level at the ear of between 68 and 83 dB (A) [mean 75.6 dB (A)]. ⋯ Nocturnal traffic noise produced a decrease in total sleep time and sleep efficiency, an increase in wakefulness and drowsiness (stage 1), as well as a decrease in REM and deep sleep stages, the last-mentioned being of statistical significance. Subjectively, the elderly subjects reported a deterioration in sleep quality due to traffic noise, an increase in middle and late insomnia, as well as a deterioration in awakening quality (dizziness, tiredness, headaches). Piridoxilate did not ameliorate these sleep disturbances.(ABSTRACT TRUNCATED AT 250 WORDS)