Wiener klinische Wochenschrift
-
Wien. Klin. Wochenschr. · Oct 2013
Multicenter StudyHuman papillomavirus in high-grade cervical lesions: Austrian data of a European multicentre study.
The purpose is to present the Austrian data of an observational, cross-sectional, multicentre study conducted in 13 European countries. This study was undertaken to assess human papillomavirus (HPV) type distribution in high-grade cervical lesions. ⋯ These Austrian data clearly demonstrate that HPV 16 is the predominant type in high-grade CIN, the immediate precursor lesions of cervical cancer. More than 60 % of the lesions were associated with HPV 16 and 18 and more than 85 % with HPV 16, 18, 31, 33 or 45. The prevalence of adenocarcinoma in situ is underestimated, since its detection is difficult with the current cytology screening.
-
Wien. Klin. Wochenschr. · May 2013
Multicenter Study Controlled Clinical TrialExchange reamed nailing compared to augmentation compression plating leaving the inserted nail in situ in the treatment of aseptic tibial non-union: a two-centre study.
A remarkable number of investigations are available treating tibial non-unions by exchange reamed nailing (ERN). Only few authors reported positive results after augmentation compression plating (ACP) for the same entity. To our knowledge no systematic study is published comparing ERN vs. ACP, so that this trial compares ACP leaving the already inserted un-reamed nail in situ against ERN in the treatment of aseptic tibial non-union, analysing success rate, time for union and operation time. ⋯ ERN and ACP with remaining pre-existing nail in situ are both safe and straightforward surgical procedures with equivalent high success rates of about 95 %. ACP has the advantage of less time for union and operating time in this series, but is associated with the disadvantage of requiring an additional incision and complaints associated to the plate requiring implant removal.
-
Wien. Klin. Wochenschr. · Feb 2012
Multicenter StudyEpidemiological and economic aspects of polytrauma management in Austria.
In Austria, treatment of multiple trauma patients has developed into an established nationwide trauma center specialty with its own unique identity. Although it represents a substantial financial investment, it ensures supply at international standards. The question of whether multiple trauma patients should be treated only in specialized trauma centers or in several hospitals remains controversial on both national and international grounds. The aim of this study was to assess Austrian trauma departments for international comparison. ⋯ The data demonstrate the broad spectrum of polytrauma treatment in Austrian trauma centers. The discussed need for centralization of polytrauma care cannot be justified based on these data. Limiting from a medical perspective, however, is the lacking comparability of quality of care due to the currently missing objective quality criteria.
-
Wien. Klin. Wochenschr. · Jan 2012
Multicenter Study Clinical TrialUse of OROS® hydromorphone in the treatment of osteoarthritis and osteoporosis: A pooled analysis of three non-interventional studies focusing on different starting doses.
To determine the effect of a lower starting dose of OROS® hydromorphone compared with a higher starting dose. ⋯ A lower starting dose was associated with better tolerability and a lower number of treatment terminations at a comparable level of pain control with high treatment satisfaction.
-
Wien. Klin. Wochenschr. · Sep 2011
Multicenter StudyClinical efficacy of OROS® hydromorphone in patients suffering from severe chronic pain: A Study undertaken in routine clinical practice.
Strong opioids are efficient drugs for treating chronic pain. In cancer patients, strong opioids are the mainstay of pain management, but in non-cancer pain caution is advised due to possible adverse effects, addictive potential and drug abuse. ⋯ The severity of patients' pain decreased during treatment with OROS hydromorphone with few adverse effects. The observed pain relief was accompanied by an improvement in the quality of the patients' lives.