Wiener klinische Wochenschrift
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Wien. Klin. Wochenschr. · Dec 2022
Observational StudyEarly administration of remdesivir may reduce mortality in hospitalized COVID-19 patients : A propensity score matched analysis.
Remdesivir is the only antiviral agent approved for the treatment of hospitalized coronavirus disease 2019 (COVID-19) patients requiring supplemental oxygen. Studies show conflicting results regarding its effect on mortality. ⋯ Remdesivir did not reduce in-hospital mortality in our whole propensity score matched cohort, but subgroup analysis showed a significant mortality reduction in female patients and in patients treated within ≤ 7 days of symptom onset. Remdesivir may reduce mortality in patients who are treated in the early stages of illness.
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Wien. Klin. Wochenschr. · Dec 2022
Which preventive control measure initiated the "flattening of the curve" : A comparison of Austria and Victoria during the 2nd wave of the COVID-19 pandemic.
When a country introduces different COVID-19 control measures over time, it is important to identify the specific measure that was effective and therefore responsible for "flattening the curve". This information helps policymakers find the right decision and saves the economy by avoiding severe yet ineffective measures. ⋯ Considering that the effect of control measures is expected the earliest one serial interval after their introduction, the control measure responsible for "flattening the curve" was the soft lockdown in Austria and the mask mandate in Victoria. The severe lockdowns in both regions were ineffective.
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Wien. Klin. Wochenschr. · Dec 2022
Observational StudyAssociation of the novel CROW-65 risk score and mortality in hospitalized kidney transplant recipients with COVID-19 : A retrospective observational study.
Kidney transplant recipients (KTR) are a group of patients with heterogeneous risks for adverse outcomes with COVID-19, but risk stratification tools in this patient group are lacking. ⋯ A novel risk score CROW-65 showed significant association with all-cause mortality in KTR yielding important hypothesis-generating findings. Further powered studies should reassess the performance of CROW-65 risk score in this population, including predictability, calibration and discrimination.
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Wien. Klin. Wochenschr. · Dec 2022
Predictors of vaccine hesitancy during the COVID-19 pandemic in Austria : A population-based cross-sectional study.
Unwillingness to get vaccinated against the coronavirus disease 2019 (COVID-19) is a major barrier in managing the pandemic. Previous studies have explored predictors of hesitancy to be vaccinated against COVID-19, but evidence on these predictors was partly mixed, and the number of assessed predictors was often limited. This study aimed to explore a wide range of potential predictors of vaccine hesitancy in a population-based cross-sectional study. ⋯ The study confirms that public health efforts targeting unvaccinated persons need to address freedom-related fears and social media discourse in order to improve vaccine uptake in the population. Particularly individuals in socially and economically disadvantaged groups and social media users need to be targeted to reduce vaccine hesitancy.