Epilepsia
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Randomized Controlled Trial Clinical Trial
Topiramate in medically intractable partial epilepsies: double-blind placebo-controlled randomized parallel group trial. Korean Topiramate Study Group.
To evaluate the efficacy and safety of topiramate (TPM) as add-on therapy in medically intractable partial epilepsies. ⋯ TPM was highly effective and safe as add-on therapy in medically intractable partial epilepsies. Slower titration of TPM might be responsible for the lesser drop-out rate than previous trials, but the incidence of AEs was still high. The AE profile of TPM in Koreans was different from that in whites.