Epilepsia
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Case Reports Clinical Trial
Chronic anterior thalamus stimulation for intractable epilepsy.
A significant number of patients with epilepsy remain poorly controlled despite antiepileptic medication (AED) treatment and are not eligible for resective surgery. Novel therapeutic methods are required to decrease seizure burden in this population. Several observations have indicated that the anterior thalamic region plays an important role in the maintenance and propagation of seizures. We investigated neuromodulation of the anterior thalamus by using deep-brain stimulation (DBS) in patients with intractable seizures. ⋯ DBS of the anterior thalamus is a safe procedure and possibly effective in patients with medically resistant seizures.