Epilepsia
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Randomized Controlled Trial Comparative Study
Onset of action of levetiracetam: a RCT trial using therapeutic intensive seizure analysis (TISA).
To correlate the onset of clinical effects of add-on levetiracetam (LEV) therapy with daily serum LEV concentration, in pharmaco-resistant focal epilepsies, using the TISA method. ⋯ The present study objectively quantified the correlation between the anticonvulsant effects of LEV in focal epilepsies and the peak serum concentration of the drug. For the first time, direct measurement was used to demonstrate the onset of action of LEV to be two days after drug initiation.