International journal of dermatology
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Glutathione (GSH) is a naturally occurring thiol that has been reported to cause skin lightening in a manner for which several mechanisms have been proposed. Highest plasma concentrations are achieved with IV administration but are accompanied by greater levels of risk. Oral administration has been less successful in elevating plasma GSH levels. ⋯ The authors conclude that the lozenge containing glutathione was safe and effective in lightening the skin of Filipino women.