Indian pediatrics
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Randomized Controlled Trial
Expressed breast milk vs 25% dextrose in procedural pain in neonates, a double blind randomized controlled trial.
To compare the effect of expressed breast milk (EBM), 25% dextrose (25 D) and sterile water (SW) on procedural pain in neonates as assessed by the premature infant pain profile (PIPP), changes in heart rate (HR), oxygen saturation (SpO2) and duration of crying. ⋯ EBM significantly reduces procedural pain in neonates though to a lesser extent as compared to 25% dextrose.
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Randomized Controlled Trial
Oral chloral hydrate vs. intranasal midazolam for sedation during computerized tomography.
We conducted this single blind randomized clinical trial to compare the efficacy and safety of oral chloral hydrate and intranasal midazolam for induction of sedation for computerized tomography scan of brain in children. Participants aged 1-10 years (n=60) were randomized to receive 100 mg/kg chloral hydrate orally with intra nasal normal saline OR intranasal midazolam 0.2 mg/kg with oral normal saline. ⋯ No significant difference was seen for side effects frequency between the two drugs (10% in chloral hydrate, 3.3% in midazolam group; P=0.34). We conclude that oral chloral hydrate can be considered as a safe and effective drug for sedation in children undergoing CT scan of brain.