Headache
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Clinical Trial
Chronic paroxysmal hemicrania and hemicrania continua. Interval between indomethacin administration and response.
The interval between indomethacin dosage and clinical response was assessed in hemicrania continua (n = 12) and chronic paroxysmal hemicrania (n = 11) sufferers. The number of trials per patient ranged from 1 to 30. At the time of testing, the patients had "considerable" pain after discontinuation of the drug. ⋯ In most patients (10 in both groups), the indomethacin effect was complete within 24 hours, and frequently within 8 hours. It is suggested that interindividual differences in dosage and timing to abolish the headaches may be due to different bioavailability or individual sensitivity. Recommendations on indomethacin testing in unilateral headaches are given.