Headache
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Randomized Controlled Trial Clinical Trial
Solubilized ibuprofen: evaluation of onset, relief, and safety of a novel formulation in the treatment of episodic tension-type headache.
To evaluate the relative efficacy of a new solubilized formulation of ibuprofen compared with acetaminophen caplets. ⋯ Although several other studies have demonstrated the overall analgesic superiority of ibuprofen to acetaminophen, this study demonstrated that the liquigel formulation also provides a clinically relevant advantage for time to analgesic effects.
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Clinical Trial
Effectiveness of amitriptyline in the prophylactic management of childhood headaches.
To study the effectiveness of a standardized dose of amitriptyline, 1 mg/kg, for childhood headaches. ⋯ Amitriptyline is an effective prophylactic medication for children with frequent headaches. A standardized dosing regimen results in a significant number of children responding with minimal side effects. The children are able to tolerate this dosing scheme and demonstrate good adherence to a dosing schedule of once a day.